Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Am Soc Mass Spectrom. 2011 Apr;22(4):607-11. doi: 10.1007/s13361-010-0072-x. Epub 2011 Feb 12.

Electron capture, collision-induced, and electron capture-collision induced dissociation in Q-TOF.

Author information

  • 1Department of Chemistry, Oregon State University, Corvallis, OR 97331, USA. valery.voinov@orst.edu

Abstract

Recently, we demonstrated that a radio-frequency-free electromagnetostatic (rf-free EMS) cell could be retrofitted into a triple quad mass spectrometer to allow electron-capture dissociation (ECD) without the aid of cooling gas or phase-specific electron injection into the cell (Voinov et al., Rapid Commun Mass Spectrom 22, 3087-3088, 2008; Voinov et al., Anal Chem 81, 1238-1243, 2009). Subsequently, we used our rf-free EMS cell in the same instrument platform to demonstrate ECD occurring in the same space and at the same time with collision-induced dissociation (CID) to produce golden pairs and even triplets from peptides (Voinov et al., Rapid Commun Mass Spectrom 23, 3028-3030, 2009). In this report, we demonstrate that ECD and CID product-ion mass spectra can be recorded at high resolution with flexible control of fragmentation processes using a newly designed cell installed in a hybrid Q-TOF tandem mass spectrometer.

© American Society for Mass Spectrometry, 2011

PMID:
21472599
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Write to the Help Desk