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Cancer Causes Control. 2011 Jun;22(6):885-97. doi: 10.1007/s10552-011-9762-3. Epub 2011 Apr 7.

Early-life sun exposure and risk of melanoma before age 40 years.

Author information

  • 1Centre for Molecular, Environmental, Genetic and Analytic (MEGA) Epidemiology, Melbourne School of Population Health, University of Melbourne, VIC, Australia. anne.cust@sydney.edu.au

Abstract

OBJECTIVE:

To examine associations between early-life sun exposure and risk of invasive cutaneous melanoma diagnosed between ages 18 and 39 years.

METHODS:

Data were analysed from 606 cases and 481 controls from the Australian Melanoma Family Study, a population-based, case-control-family study. Self- and parent-reported sun exposure was collected by interview. Odds ratios (OR) were estimated using unconditional logistic regression, adjusted for potential confounders.

RESULTS:

Self-reported childhood total sun exposure was not associated with melanoma overall, but was positively associated with melanoma diagnosed at 18-29 years of age (OR for highest vs. lowest quartile: 3.21, 95% confidence intervals (CI) 1.38-7.44; P (trend) 0.02; P (interaction) by age group 0.09). Analyses restricted to participants whose self-reported sun exposure was concordant with that recalled by their parents gave an OR for the highest versus lowest tertile of childhood total sun exposure of 2.28 (95% CI 1.03-5.04; P (trend) 0.05), and for any versus no severe childhood sunburn of 2.36 (95% CI 1.05-5.31). The association of self-reported severe sunburn with melanoma was evident only in people who tended to tan rather than burn and in people who had few nevi.

CONCLUSION:

The association of early-life sun exposure with early-onset melanoma is influenced by host factors.

PMID:
21472378
[PubMed - indexed for MEDLINE]
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