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Front Neurol. 2011 Mar 24;2:16. doi: 10.3389/fneur.2011.00016. eCollection 2011.

Effects of donepezil on behavioral manifestations of thalamic infarction: a single-case observation.

Author information

  • 1Cognitive Neurology and Dementia Unit, Neurology Service, El Salvador Hospital Santiago, Chile.

Abstract

OBJECTIVE:

To examine the effect of donepezil for the treatment of cognitive and behavioral disorders associated with thalamic lesions in a 45-year-old male who suffered an infarct in the left thalamus.

BACKGROUND:

Recent studies suggest that donepezil may improve executive functions impairments due to subcortical ischemic lesions.

METHOD:

The effects of donepezil were analyzed in a single-case of thalamic infarction with cognitive and behavioral alterations in an open label study.

RESULTS:

Significant behavioral modifications related to improved performances in executive functions were observed with the treatment.

CONCLUSION:

The results suggest that donepezil may have significant effect on executive functions that can alter behavioral outcomes after thalamic infarctions.

KEYWORDS:

donepezil; dysexecutive syndrome; stroke; thalamus; vascular dementia; vascular subcortical cognitive impairment

PMID:
21472029
[PubMed]
PMCID:
PMC3066464
Free PMC Article
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