Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Radiology. 2011 Jun;259(3):834-43. doi: 10.1148/radiol.11101975. Epub 2011 Apr 6.

Mild cognitive impairment: baseline and longitudinal structural MR imaging measures improve predictive prognosis.

Collaborators (1091)

Saradha A, Abdi H, Abdulkadir A, Abeliovich A, Abellan van Kan G, Acharya D, Aghajanian J, Agrusti A, Agyemang A, Ahdidan J, Ahmed S, Ahn JE, Aisen P, Aksu Y, Al-Akhras M, Alberca R, Alexander D, Alin A, Almeida F, Amlien I, Anand S, Anderson D, Andrew M, Angersbach S, Aoyama E, Appannah A, Arfanakis K, Armor T, Arrighi M, Arunagiri V, Asatryan A, Ashe-McNalley C, Ashford W, Ashiga H, Assareh A, Le Page A, Avants B, Avinash G, Aviv R, Awasthi S, Ayan-Oshodi M, Babic T, Baek Y, Bagepally B, Bai S, Baird G, Baker J, Banks S, Bard J, Barnes J, Bartlett J, Bartzokis G, Barua N, Bauer C, Bayley P, Beck I, Becker JA, Becker J, Beckett L, Bednar M, Beg MF, Bek S, Bekris L, Belaroussi B, Belmokhtar N, Bernard C, Bertram L, Bhaskar U, Bienkowska K, Biffi A, Bigler E, Bilgic B, Bishop C, Bishop C, Bittner D, Black R, Bogorodzki P, Bokde A, Bonner-Jackson A, Boppana M, Borrie M, Bourgeat P, Bowes M, Bowman G, Bowman D, Braskie M, Braunewell K, Breitner J, Bresell A, Brewer J, Brickman A, Britschgi M, Broadbent S, Brogren J, Brooks D, Brunton S, Buchert R, Buchsbaum M, Buckley C, Buerger K, Burnham S, Burns J, Burton D, Butler T, Cabeza R, Cairns N, Callhoff J, Calvini P, Cantillon M, Carbotti A, Cardona-Sanclemente LE, Carle A, Carmasin J, Carranza-Athó F, Carvalho J, Casabianca J, Casanova R, Cash D, Cedarbaum J, Cella M, Celsis P, Chakravarty M, Chanu P, Chao L, Charil A, Chemali Z, Chen R, Chen K, Chen J, Chen G, Chen W, Chen S, Chen M, Cheng WC, Cherkas Y, Chertkow H, Cheung C, Cheung V, Chiang G, Chiba K, Chin S, Ching C, Chisholm J, Cho Y, Cho C, Choe J, Choubey S, Chowbina S, Christensen AL, Clark D, Clark C, Clarkson M, Clunie D, Coen M, Coimbra A, Coimbra A, Compton D, Coppola G, Coulin S, Cover KS, Crane P, Crans G, Croop R, Crowther D, Crum W, Cui Y, Curry C, Cutter G, Daiello L, Dake M, Dale A, Daliri MR, Damato VD, Darby E, Darkner S, Darkner S, Davatzikos C, Dave J, David R, DavidPrakash B, de Bruijne M, De Meyer G, De Nunzio G, DeCarli C, Dechairo B, DeDuck K, Dehghan H, Dejkam A, Delfino M, Della Rosa PA, Dellavedova L, Delpassand E, Delrieu J, DeOrchis V, Dépy Carron D, Desjardins B, deToledo-Morrell L, Devanand D, Devous M, Di X, Diaz-Arrastia R, Dickerson B, Ding X, Dinov I, Dobson H, Dodge H, Dolman A, Donohue M, Dore V, Dorflinger E, Dowling M, Dowling M, Duan X, Dubal D, Duchesne S, Duff K, Dukart J, Durazzo T, Dykstra K, Earl N, Edula G, Ekin A, Elcoroaristizabal X, Emahazion T, Emahazion T, Engelman C, Epstein N, Erten-Lyons D, Eskildsen S, Falcone G, Fan Y, Fan L, Farahibozorg S, Farb N, Farias S, Farnum M, Farrer L, Farzan A, Faux N, Feldman B, Feldman H, Feldman S, Fennema-Notestine C, Fernandes M, Fernandez E, Ferreira MJ, Ferrer E, Fetterman B, Figurski M, Filipovych R, Fillit H, Finch S, Finlay D, Fiot JB, Flenniken D, Fletcher E, Fletcher PT, Flynn Longmire C, Focke N, Forman M, Forsythe A, Fox S, Fox-Bosetti S, Franco-Villalobos C, Franko E, Freeman S, Friedrich CM, Friesenhahn M, Frings L, Frisoni G, Fritzsche K, Fujimoto Y, Fujiwara K, Fullerton T, Gallins P, Galvin B, Gamst A, Gan K, Garcia MT, Garg G, Gaser C, Gastineau E, Gauthier S, Gavett B, Gavidia G, Gazdzinski S, Ge Q, Ge T, Gemme G, Geraci J, Ghassabi Z, Ghosh D, Gieschke R, Gil JE, Gill R, Gitelman D, Gleason C, Glymour MM, Godbey M, Goghari V, Gold M, Goldberg T, Goldman J, Gomeni R, Gonzales C, Goodro R, Gordon B, Gore C, Gorriz JM, Grachev I, Grandey E, Grasela T, Gratt J, Gray K, Greenberg B, Gregory E, Greicius M, Greve D, Grill J, Gross A, Gross A, Guignot I, Guo J, Guo Q, Guo H, Guo L, Guyot J, Habeck C, Hai Y, Haight T, Hajaj C, Hammarstrom P, Hampel H, Han D, Han J, Hanif M, Hanna Y, Hardy P, Harvey D, Hasan MK, Hayashi T, He H, He Y, Head D, Head D, Heckemann R, Heidebrink J, Hellyer P, Henderson D, Henrard S, Herholz K, Hernandez M, Herskovits AZ, Hess C, Hildenbrand M, Ho Ming AY, Hobart J, Hofer S, Hoffman J, Holder D, Hollingworth P, Holmes R, Honigberg L, Hope T, Hoppin J, Hou Y, Hu Z, Hu X, Hu W, Hu M, Huang F, Huang CC, Huang C, Huang SP, Huang S, Huang J, Huang CJ, Hubbard R, Huentelman M, Huppertz HJ, Hurko O, Hurt S, Hwang S, Hyun J, Ifeachor E, Iglesias M, Ikari Y, Ikonomidou V, Imani F, Immermann F, Inlow M, Inoue L, Insel P, Irizarry M, Irungu Bm, Ishibashi T, Ishii K, Ismail S, Ito K, Iturria-Medina Y, Iwatsubo T, Jacobson M, Jacqmin P, Jafari A, Jafari-Khouzani K, Jaffe C, Jagust W, Jagust W, Jara H, Jasperse B, Jedynak B, Jefferson A, Jennings JR, Jessen W, Jia F, Jiang T, Jing H, Johnson J, Johnson S, Johnson DK, Jones R, Joshi S, Jouvent E, Juengling F, Juh R, Julin P, Junjie Z, Uday Bhaskar K, Kadish B, Kahle-Wrobleski K, Kairui Z, Kallam HR, Kamboh MI, Kanchev V, Kaneko T, Kaneta T, Kang JH, Karageorgiou E, Karantzoulis S, Karlawish J, Katz E, Kaushik SS, Kauwe J, Kauwe J, Kawakami H, Kazimipoor B, Kelleher T, Kennedy R, Kerchner G, Kerrouche N, Keshava N, Khalil I, Khalil A, Kihara T, Killeen N, Killiany R, Kim A, Kim H, Kim JH, Kim Y, Kim H, Kim S, Kim H, Kimberg D, Kimura T, King R, Kirby J, Kirsch W, Klimas M, Kline R, Kling M, Klopfenstein E, Koikkalainen J, Kokomoor A, Kolasny A, Koppel J, Korolev I, Kotran N, Kouassi A, Kowalczyk A, Krams M, Kratzer M, Kuceyeski A, Kuhn FP, Kumar S, Roy PK, Kuo J, Kuo HT, Kurosawa K, Kwon OH, Labrish C, Laforet G, Lai S, Lakatos A, Lam OK, Lampron A, Landau S, Lane R, Lane B, Langbaum J, Langford D, Lanius V, Latella M, Laxamana J, Leahy R, Lee N, Lee JM, Lee V, Lee JH, Lee G, Lee D, Lefkimmiatis S, Lemaitre H, Lenfant P, Lenz R, Leoutsakos JM, Lester G, Levey A, Li SJ, Li S, Li G, Li W, Li X, Li M, Li L, Li J, Li CS, Li R, Li Q, Li Y, Liang K, Liang L, Liang P, Liao YL, Lin AL, Lin M, Lin LC, Lin L, Liu P, Liu L, Liu D, Liu W, Liu S, Liu Y, Liu M, Liu L, Liu H, Liu S, Liu X, Liu T, Liu S, Lo R, Lobanov V, Loewenstein D, Logovinsky V, Long X, Long Z, Long M, Looi J, Lu PH, Lu H, Lukas C, Lukic A, Lull JJ, Luo X, Lynch J, Ma L, Ma SM, Mackin S, Mada M, Magda S, Maglio S, Mahanta MS, Maikusa N, Mak HK, Malave V, Maldjian J, Mandal P, Mangin JF, Manjon J, Mantri N, Manzour A, Marambaud P, Marchewka A, Marek K, Margolin R, Markind S, Marrett S, Marshall G, Martinez Torteya A, Mather M, Mathis C, Matoug S, Matsuo Y, Mattei P, Matthews D, McArdle J, McCarroll S, McEvoy L, McGeown W, McGonigle J, McIntyre J, McLaren D, McQuail J, Meadowcroft M, Meda S, Mehta N, Melie-Garcia L, Melrose R, Mendonca B, Menendez M, Meredith J, Merrill D, Mesulam MM, Metti A, Meyer C, Mez J, Mickael G, Miftahof R, Mikhno A, Mikula M, Miller D, Millikin C, Min Y, Mirza M, Mistridis P, Mitchell M, Mitsis E, Mohan A, Moore D, Moradi Birgani P, Moratal D, Morimoto B, Mormino E, Mortamet B, Moscato P, Mueller N, Mueller K, Mueller S, Mukherjee S, Mulder E, Mungas D, Murayama S, Murphy M, Murray B, Myers A, Nair A, Najafi S, Nazarparvar B, Nazeri A, Nettiksimmons J, Neu S, Ng YB, Nguyen N, Nguyen Xuan T, Nichols T, Nicodemus K, Niecko T, Nielsen C, Notomi K, Nutakki GC, O'Bryant S, O'Neil A, Obisesan T, Oh DH, Oh J, Okonkwo O, Olde Rikkert M, Oliveira A, Olmos S, Ortner M, Ostrowitzki S, Oswald A, Ourselin S, Ouyang G, Overholser R, Anishiya P, Pa J, Pan Z, Pande Y, Pardo J, Pardoe H, Park L, Park MH, Park Sh, Park KH, Park H, Park S, Paskavitz J, Patel Y, Patil M, Pawlak M, Payoux P, Pearson J, Peavy G, Pell G, Peng Y, Pennec X, Pepin Jl, Perneczky R, Petitti D, Petrella J, Peyrat JM, Pezoa J, Phillips J, Phillips N, Pian WT, Pierson R, Piovezan M, Podhorski A, Pollari M, Pontecorvo M, Popov V, Poppenk J, Posner H, Potkin S, Potter G, Potter E, Prasad G, Prenger K, Prince J, Priya A, Puchakayala SR, Puchakayala SR, Qiu R, Qiu W, Qualls CD, Rajeesh R, Rallabandi VP, Ramage A, Randolph C, Rao A, Rao D, Raubertas R, Ray D, Razak H, Reed B, Reid A, Reilhac A, Reinsberger C, Restrepo L, Retico A, Ribbens A, Richard E, Richards J, Riddle W, Ries M, Rischall M, Rizk-Jackson A, Robieson W, Rocha-Rego V, Rogalski E, Rogers E, Rojas I, Rojas Balderrama J, Romero K, Rorden C, Rosand J, Rosen A, Rosen O, Rosenberg P, Ross D, Roubini E, Rousseau F, Rowe C, Rubin D, Rubright J, Ruiz A, Rulseh A, Rusinek H, Ryan L, Saad A, Sabbagh M, Sabuncu M, Sachs M, Sadeghi A, Said Y, Sakata M, Salat D, Salmon D, Salter H, Samwald M, Sanchez L, Sanders E, Sanders E, Sanjo N, Sarnel H, Sato S, Sato H, Saumier D, Savio A, Saykin A, Schaffer JD, Scharre D, Schegerin M, Schlosser G, Schmand B, Schmansky N, Schmidt M, Schmidt-Wilcke T, Schneider L, Schramm H, Schuerch M, Schwartz E, Schwartz C, Schwarz A, Schwarz J, Seixas F, Selnes P, Senjem M, Senlin W, Seo SW, Sethuraman G, Sevigny J, Sevigny J, Sfikas G, Sghedoni R, Shah SK, Shahbaba B, Shams S, Shattuck D, Shaw L, Shaw L, Sheela J, Shen J, Shen W, Shen Q, Shera D, Sherman J, Sherva R, Shi F, Shi J, Shukla V, Shuler C, Shulman J, Sideris K, Siegel R, Siemers E, Silveira M, Silver M, Silverman D, Sim I, Simmons A, Simmons A, Simoes R, Simon M, Simpson I, Singh SP, Singh N, Sinha N, Siuciak J, Sjögren N, Skinner J, Skup M, Small G, Smith B, Smith C, Smith M, Smyth T, Snow S, Snyder P, Soares H, Soldea O, Solomon P, Solomon A, Som S, Song C, Song M, Sosova I, Soudah E, Soydemir M, Spampinato MV, Spenger C, Sperling R, Spiegel, Squarcia S, Squire L, Staff R, Stern Y, Straw J, Stricker N, Strittmatter S, Stühler E, Styren S, Subramanian V, Sugishita M, Sukkar R, Sun J, Sun Y, Sun Y, Sun J, Sundell K, Suri M, Suzuki A, Svetnik V, Swan M, Szoeke C, Takahasi T, Takeuchi T, Tanaka S, Tanaka R, Tanchi C, Tancredi D, Tao W, Tao D, Tarnow E, Tassy D, Tauber C, Taylor-Reinwald L, Teng E, Terlizzi R, Thames A, Thatavarti RS, Thiele F, Thomas R, Thomas B, Thompson W, Thompson W, Thompson P, Thornton-Wells T, Thorvaldsson V, Thurfjell L, Titeux L, Tokuda T, Toledo JB, Tölli T, Toma A, Tomita N, Toro R, Torrealdea P, Tosto G, Tosun D, Tousian M, Toussaint P, Toyoshiba H, Tractenberg RE, Trittschuh E, Trojanowski J, Truran D, Tsanas A, Tsechpenakis G, Tucker-Drob E, Tufail A, Tung J, Turken A, Ueda Y, Uematsu D, Ullrich L, Umadevi Venkataraju K, Umar N, Ungar L, Uzunbas G, Van de Nes J, van der Brug M, van der Lijn F, Van Hecke W, Van Horn J, Van Leemput K, Van Train K, Vasanawala M, Vemuri P, Verwaerde P, Videbaek C, Vidoni E, Villanueva-Meyer J, Visser PJ, Vitolo O, Vounou M, Wade S, Walhovd KB, Wan H, Wang LS, Wang H, Wang A, Wang YM, Wang Y, Wang L, Wang X, Wang Z, Wang Y, Wang T, Wang A, Wang W, Wang H, Wang Y, Wang L, Ward A, Ward M, Warfield S, Watanabe T, Webb D, Wei L, Weiner M, Wen SH, Wenjing L, Wenzel F, Westlye LT, Whitcher B, Whitlow C, Wilhelmsen K, Williams D, Wilmot B, Wilson L, Wimsatt M, Wingo T, Wiste H, Wolke I, Wolz R, Wong K, Woo J, Woo E, Woods L, Worth E, Worth A, Wouters H, Wu T, Wu X, Wu E, Wu L, Wu YG, Wyman B, Wyss-Coray T, Xiao L, Xiao G, Xie S, Xu S, Xu Y, Xu YZ, Xu J, Xu G, Yamane T, Yamashita F, Yan P, Yan Y, Yan Y, Yang W, Yang E, Yang HD, Yang J, Yang CY, Yang QX, Yang Z, Yang Z, Yang G, Yassa M, Ye L, Ye BS, Ye J, Ye J, Yee L, Ying S, Yoo B, Young J, Yu S, Yu D, Yuan G, Yuan K, Yuen B, Yushkevich P, Zaborszky L, Zagorodnov V, Zagorski M, Zarei M, Zawadzki R, Zeitzer J, Zelinski E, Zhang Z, Zhang L, Zhang H, Zhang T, Zhang H, Zhang X, Zhang P, Zhang B, Zhang J, Zhang L, Zhao Q, Zhao J, Zhao P, Zhen X, Zhen X, Zhijun Y, Zhou S, Zhou B, Zhou L, Zhu W, Zhu H, Zhu W, Zilka S, Zito G, Zou H.

Author information

  • 1Department of Radiology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA. lkmcevoy@ucsd.edu

Abstract

PURPOSE:

To assess whether single-time-point and longitudinal volumetric magnetic resonance (MR) imaging measures provide predictive prognostic information in patients with amnestic mild cognitive impairment (MCI).

MATERIALS AND METHODS:

This study was conducted with institutional review board approval and in compliance with HIPAA regulations. Written informed consent was obtained from all participants or the participants' legal guardians. Cross-validated discriminant analyses of MR imaging measures were performed to differentiate 164 Alzheimer disease (AD) cases from 203 healthy control cases. Separate analyses were performed by using data from MR images obtained at one time point or by combining single-time-point measures with 1-year change measures. Resulting discriminant functions were applied to 317 MCI cases to derive individual patient risk scores. Risk of conversion to AD was estimated as a continuous function of risk score percentile. Kaplan-Meier survival curves were computed for risk score quartiles. Odds ratios (ORs) for the conversion to AD were computed between the highest and lowest quartile scores.

RESULTS:

Individualized risk estimates from baseline MR examinations indicated that the 1-year risk of conversion to AD ranged from 3% to 40% (average group risk, 17%; OR, 7.2 for highest vs lowest score quartiles). Including measures of 1-year change in global and regional volumes significantly improved risk estimates (P = 001), with the risk of conversion to AD in the subsequent year ranging from 3% to 69% (average group risk, 27%; OR, 12.0 for highest vs lowest score quartiles).

CONCLUSION:

Relative to the risk of conversion to AD conferred by the clinical diagnosis of MCI alone, MR imaging measures yield substantially more informative patient-specific risk estimates. Such predictive prognostic information will be critical if disease-modifying therapies become available.

SUPPLEMENTAL MATERIAL:

http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.11101975/-/DC1.

RSNA, 2011

PMID:
21471273
[PubMed - indexed for MEDLINE]
PMCID:
PMC3099042
Free PMC Article

Images from this publication.See all images (14)Free text

Figure 1:
Figure 2a:
Figure 2b:
Figure 2c:
Figure 2d:
Figure 3a:
Figure 3b:
Figure 3c:
Figure 3d:
Figure 4a:
Figure 4b:
Figure 5a:
Figure 5b:
Figure 5c:
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Atypon Icon for PubMed Central
    Loading ...
    Write to the Help Desk