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Psychophysiology. 2011 Oct;48(10):1448-55. doi: 10.1111/j.1469-8986.2011.01201.x. Epub 2011 Apr 1.

Age-related differences in corticospinal excitability during a Go/NoGo task.

Author information

  • 1Human Motor Control Laboratory, School of Psychology, University of Tasmania, Hobart, Tasmania, Australia. Hakuei.Fujiyama@utas.edu.au


Age-related slowing of reaction times (RTs) is well documented but whether the phenomenon reflects deficits in movement preparation and/or response generation processes is unclear. To gain further insight into this issue, transcranial magnetic stimulation (TMS) was used to investigate motor cortex (M1) excitability and short-interval intracortical inhibitory (SICI) processes during a Go/NoGo RT task in younger and older adults. Single- and paired-pulse TMS was delivered over the left M1 during preparation and response generation periods in a right-hand muscle. Younger adults had shorter RTs and a larger increase in corticospinal excitability at response generation period than older adults. SICI modulation for both groups showed a large reduction in inhibition immediately prior to EMG onset. These findings indicate age-related differences in corticospinal excitability during the response generation stage of sensorimotor information processing.

Copyright © 2011 Society for Psychophysiological Research.

[PubMed - indexed for MEDLINE]
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