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Autophagy. 2011 Jun;7(6):664-5. Epub 2011 Jun 1.

Presenilins mediate efficient proteolysis via the autophagosome-lysosome system.

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  • 1Department of Neurobiology and Behavior, Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, USA.


Degradation through the lysosome involves careful orchestration of numerous molecular players in concert. Many of these key molecular players remain to be identified. We find that wild-type presenilins play a key role in degradation through the autophagy-lysosome system by modulating either fusion of autophagosomes to lysosomes or lysosome function.

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