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Department of Genetics, Stanford University, Stanford, CA 94305, USA. anne.brunet@stanford.edu
Cutting down calories prolongs life, but how this works remains largely unknown. A recent study in Nature (Mair et al., 2011) shows that life span extension triggered by the energy-sensing protein kinase AMPK is mediated by an evolutionarily conserved transcriptional circuit involving CRTC-1 and CREB.
Copyright © 2011 Elsevier Inc. All rights reserved.
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