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Cell Metab. 2011 Apr 6;13(4):358-60. doi: 10.1016/j.cmet.2011.03.012.

A CRTCal link between energy and life span.

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  • 1Department of Genetics, Stanford University, Stanford, CA 94305, USA.


Cutting down calories prolongs life, but how this works remains largely unknown. A recent study in Nature (Mair et al., 2011) shows that life span extension triggered by the energy-sensing protein kinase AMPK is mediated by an evolutionarily conserved transcriptional circuit involving CRTC-1 and CREB.

Copyright © 2011 Elsevier Inc. All rights reserved.

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