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Leuk Res. 2011 Jul;35(7):971-3. doi: 10.1016/j.leukres.2011.03.011. Epub 2011 Apr 1.

Rac-1 GTPase controls the capacity of human leukaemic lymphoblasts to migrate on fibronectin in response to SDF-1α (CXCL12).

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  • 1Laboratoire MERCI (EA3829), Rouen University, and Department of Haematology, Rouen University Hospital, Rouen, France.


Acute lymphoblastic leukaemia (ALL) is characterized by malignant cell infiltration of bone marrow, requiring chemotactic response to SDF-1α. Using time-lapse video, we measured the velocity of ALL cells on fibronectin, and found that SDF-1α increased their migration activity for 2 h, but had no effect after 4h, following internalization of its receptor CXCR4. Transfection of ALL cells with dominant-negative Rac1 mutant significantly prolonged their chemotactic response to SDF-1α, and this effect was associated with an alteration of CXCR4 internalization. These data suggest a regulatory role for Rac1 in the chemotactic response of ALL cells to SDF-1α via receptor processing.

Copyright © 2011 Elsevier Ltd. All rights reserved.

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