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    Fertil Steril. 2011 Jun 30;95(8):2574-7. doi: 10.1016/j.fertnstert.2011.02.047. Epub 2011 Apr 2.

    Prevalence of hypospadias in grandsons of women exposed to diethylstilbestrol during pregnancy: a multigenerational national cohort study.

    Kalfa N, Paris F, Soyer-Gobillard MO, Daures JP, Sultan C.

    Source

    Unité d'Endocrinologie-Gynécologie Pédiatrique, Service de Pédiatrie I, Hôpital Arnaud de Villeneuve, CHU Montpellier and Université Montpellier, France.

    Abstract

    Prenatal diethylstilbestrol (DES)-exposed mice have raised the suspicion of a transgenerational effect in the occurrence of genital malformation in males. This nationwide cohort study in collaboration with a French association of DES-exposed women studied 529 families and showed that a significant proportion of boys born to DES daughters exhibited hypospadias with no other molecular defects identified.

    Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

    PMID:
    21458804
    [PubMed - indexed for MEDLINE]

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