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Microbes Infect. 2011 Aug;13(8-9):731-41. doi: 10.1016/j.micinf.2011.03.006. Epub 2011 Mar 31.

The molecular biology of human herpesvirus-6 latency and telomere integration.

Author information

  • 1Department of Molecular Medicine, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA.

Abstract

The genomes of herpesviruses establish latency as a circular episome. However, Human herpesvirus-6 (HHV-6) has been shown to specifically integrate into the telomeres of chromosomes during latency and vertically transmit through the germ-line. This review will focus on the telomere integration of HHV-6, the potential viral and cellular genes that mediate integration, and the clinical impact on the host.

Copyright © 2011 Institut Pasteur. Published by Elsevier SAS. All rights reserved.

PMID:
21458587
[PubMed - indexed for MEDLINE]
PMCID:
PMC3130849
Free PMC Article

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