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J Muscle Res Cell Motil. 2011 Aug;32(1):7-17. doi: 10.1007/s10974-011-9246-9. Epub 2011 Apr 1.

The actin associated protein palladin in smooth muscle and in the development of diseases of the cardiovasculature and in cancer.

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  • 1Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA.


Palladin is an actin associated protein serving as a cytoskeleton scaffold, and actin cross linker, localizing at stress fibers, focal adhesions, and other actin based structures. Recent studies showed that palladin plays a critical role in smooth muscle differentiation, migration, contraction, and more importantly contributes to embryonic development. This review will focus on the functions and possible mechanisms of palladin in smooth muscle and in pathological conditions such as cardiovascular diseases and cancers.

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