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Genome Biol. 2011;12(3):R32. doi: 10.1186/gb-2011-12-3-r32. Epub 2011 Mar 31.

The CRIT framework for identifying cross patterns in systems biology and application to chemogenomics.

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  • 1Department of Genetics, 77 Ave. of Louis Pasteur, Harvard Medical School, Boston, MA 02115, USA.


Biological data is often tabular but finding statistically valid connections between entities in a sequence of tables can be problematic--for example, connecting particular entities in a drug property table to gene properties in a second table, using a third table associating genes with drugs. Here we present an approach (CRIT) to find connections such as these and show how it can be applied in a variety of genomic contexts including chemogenomics data.

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