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Opt Express. 2011 Mar 28;19(7):6623-34. doi: 10.1364/OE.19.006623.

In vivo three-dimensional optical coherence elastography.

Author information

  • 1Optical + Biomedical Engineering Laboratory, School of Electrical, Electronic and Computer Engineering, The University of Western Australia, Crawley, Western Australia, Australia. brendank@ee.uwa.edu.au

Abstract

We present the first three-dimensional (3D) data sets recorded using optical coherence elastography (OCE). Uni-axial strain rate was measured on human skin in vivo using a spectral-domain optical coherence tomography (OCT) system providing >450 times higher line rate than previously reported for in vivo OCE imaging. Mechanical excitation was applied at a frequency of 125 Hz using a ring actuator sample arm with, for the first time in OCE measurements, a controlled static preload. We performed 3D-OCE, processed in 2D and displayed in 3D, on normal and hydrated skin and observed a more elastic response of the stratum corneum in the hydrated case.

PMID:
21451690
[PubMed - indexed for MEDLINE]
PMCID:
PMC3308196
Free PMC Article
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