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Curr Opin Neurobiol. 2011 Apr;21(2):306-12. doi: 10.1016/j.conb.2011.03.001. Epub 2011 Mar 28.

PSD-95-like membrane associated guanylate kinases (PSD-MAGUKs) and synaptic plasticity.

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  • 1Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02319, United States. weifeng@mit.edu

Abstract

Activity-dependent modification of excitatory synaptic transmission is a fundamental mechanism for developmental plasticity of the neural circuits and experience-dependent plasticity. Synaptic glutamatergic receptors including AMPA receptors and NMDA receptors (AMPARs and NMDARs) are embedded in the postsynaptic density, a highly organized protein network. Overwhelming data have shown that PSD-95-like membrane associated guanylate kinases (PSD-MAGUKs), a major family of scaffold proteins at glutamatergic synapses, regulate basal synaptic AMPAR function and trafficking. It is now clear that PSD-MAGUKs have multifaceted functions in regulating both basal synaptic transmission and synaptic plasticity. Here we discuss recent advancements in understanding the roles of PSD-95 and other family members of PSD-MAGUKs in synaptic plasticity, both as an anchoring protein for synaptic AMPARs and as a signaling scaffold for mediating the interaction of the signaling complex and NMDARs.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
21450454
[PubMed - indexed for MEDLINE]
PMCID:
PMC3138136
Free PMC Article
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