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World J Gastroenterol. 2011 Mar 7;17(9):1204-10. doi: 10.3748/wjg.v17.i9.1204.

Coffee drinking and pancreatic cancer risk: a meta-analysis of cohort studies.

Author information

  • 1Department of Gastroenterology, Huadong Hospital, Fudan University, Shanghai 200040, China.

Abstract

AIM:

To quantitatively assess the relationship between coffee consumption and incidence of pancreatic cancer in a meta-analysis of cohort studies.

METHODS:

We searched MEDLINE, EMBASE, Science Citation Index Expanded and bibliographies of retrieved articles. Studies were included if they reported relative risks (RRs) and corresponding 95% CIs of pancreatic cancer with respect to frequency of coffee intake. We performed random-effects meta-analyses and meta-regressions of study-specific incremental estimates to determine the risk of pancreatic cancer associated with a 1 cup/d increment in coffee consumption.

RESULTS:

Fourteen studies met the inclusion criteria, which included 671,080 individuals (1496 cancer events) with an average follow-up of 14.9 years. Compared with individuals who did not drink or seldom drank coffee per day, the pooled RR of pancreatic cancer was 0.82 (95% CI: 0.69-0.95) for regular coffee drinkers, 0.86 (0.76-0.96) for low to moderate coffee drinkers, and 0.68 (0.51-0.84) for high drinkers. In subgroup analyses, we noted that, coffee drinking was associated with a reduced risk of pancreatic cancer in men, while this association was not seen in women. These associations were also similar in studies from North America, Europe, and the Asia-Pacific region.

CONCLUSION:

Findings from this meta-analysis suggest that there is an inverse relationship between coffee drinking and risk of pancreatic cancer.

KEYWORDS:

Coffee; Cohort study; Meta-analysis; Pancreatic neoplasm

PMID:
21448427
[PubMed - indexed for MEDLINE]
PMCID:
PMC3063915
Free PMC Article

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