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Med Sci (Paris). 2011 Mar;27(3):285-8. doi: 10.1051/medsci/2011273285. Epub 2011 Mar 30.

[Mesenchymal stem cells: weapons or dangers for cancer treatment?].

[Article in French]

Author information

  • Inserm U844, site Saint Éloi, bâtiment INM, 80, rue Augustin Fliche, Montpellier, F-34091, France. gwendal.lazennec@inserm.fr

Abstract

Mesenchymal stem cells (MSC) have attracted recent attention for their cell therapy potential, based in particular on their immunosuppressive properties, which have served as the basis for the treatment of autoimmune diseases. Interestingly, MSC have been used in cell therapy strategies to deliver therapeutical genes. Cell therapy approaches taking advantages of MSC have been proposed, as MSC display a potential tropsim for tumors. However, all these strategies raise a series of questions about the safety of MSC, as MSC could enhance tumor growth and metastasis. This review summarizes recent findngs about MSC in carcinogenesis.

© 2011 médecine/sciences - Inserm / SRMS.

PMID:
21447301
[PubMed - indexed for MEDLINE]
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