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Clin Oral Implants Res. 2012 May;23(5):556-9. doi: 10.1111/j.1600-0501.2011.02175.x. Epub 2011 Mar 28.

Platform switching and matrix metalloproteinase-8 levels in peri-implant sulcular fluid.

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The concept of platform switching has been introduced to implant therapy, however long-term data are sparse. The aim of this study was to biochemically investigate the inflammatory response mediated by MMP-8 to platform switching after 3 years of loading, in order to understand the long-term effect of implant/abutment mismatching on peri-implant health.


A total of 70 implants had been inserted in the posterior maxilla in 26 patients and were randomly assigned to one of the four treatment regimens (implant diameter 3.8 [control group], 4.3 [Test group 1, T(1)], 4.8 [Test group 2, T(2)] and 5.5 mm [Test group 3, T(3)]). All implants were restored using a 3.8 mm abutment. In the test groups, this restoration resulted in a mismatching of 0.25-0.85 mm of implant-abutment diameters.


Thirty-six months after prosthetic rehabilitation, peri-implant sulcular fluid samples were taken from two aspects of all implants and from periodontally healthy adjacent teeth. Samples were processed in a conventional ELISA using monoclonal antibodies recognizing the active entity of MMP-8. In the test groups, MMP-8 mean values were 2.76 ng for T(1) (SD: 2.91), 3.30 ng for T(2) (SD: 1.94) and 3.18 ng for T(3) (SD: 2.46). For the control group, MMP-8 mean value was 3.6 ng (SD: 2.23), whereas 3.38 ng (SD: 2.2) was recorded at the adjacent teeth. There were no statistically significant differences in MMP-8 values between the groups (P=0.113, Kruskal-Wallis).


The presence of an implant/abutment mismatching specific for this prosthetic concept is compatible with long-term peri-implant health as demonstrated by analysis of a sensitive biomarker of the peri-implant inflammatory response.

© 2011 John Wiley & Sons A/S.

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