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Crit Care Clin. 2011 Apr;27(2):e1-27. doi: 10.1016/j.ccc.2010.12.001.

Antimicrobial therapy of sepsis and septic shock--when are two drugs better than one?

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  • 1Department of Internal Medicine, Section of Infectious Diseases, University of Wisconsin Hospital and Clinics, 1685 Highland Avenue, Madison, WI 53705, USA.

Abstract

In clinical practice, physicians frequently use combination therapy despite the conflicting evidence for its effectiveness. The results of recent studies have contributed to our understanding of this important issue. In this article, we examine the evidence for, or against, the use of combination drug therapy compared with monotherapy in the management of serious infections, sepsis, and septic shock.

Copyright © 2011 Elsevier Inc. All rights reserved.

PMID:
21440195
[PubMed - indexed for MEDLINE]
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