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Immunity. 2011 Apr 22;34(4):579-89. doi: 10.1016/j.immuni.2011.02.015.

CD94 is essential for NK cell-mediated resistance to a lethal viral disease.

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  • 1Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

Abstract

It is well established that natural killer (NK) cells confer resistance to many viral diseases, but in only a few instances the molecular mechanisms whereby NK cells recognize virus-infected cells are known. Here we show that CD94, a molecule preferentially expressed by NK cells, is essential for the resistance of C57BL/6 mice to mousepox, a disease caused by the Orthopoxvirus ectromelia virus. Ectromelia virus-infected cells expressing the major histocompatibility complex (MHC) class Ib molecule Qa-1(b) are specifically recognized by the activating receptor formed by CD94 and NKG2E. Because CD94-NKG2 receptors and their ligands are highly conserved in rodents and humans, a similar mechanism may exist during human infections with the smallpox and monkeypox viruses, which are highly homologous to ectromelia virus.

Copyright © 2011 Elsevier Inc. All rights reserved.

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PMID:
21439856
[PubMed - indexed for MEDLINE]
PMCID:
PMC3081423
Free PMC Article

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