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Virol J. 2011 Mar 25;8:139. doi: 10.1186/1743-422X-8-139.

Rapid detection of anti-Vaccinia virus neutralizing antibodies.

Author information

  • 1Robert Koch-Institute, Centre for Biological Safety, Nordufer 20, 13353 Berlin, Germany.

Abstract

Increasing infections with Monkeypox and Cowpox viruses pose a continuous and growing threat to human health. The standard method for detecting poxvirus neutralizing antibodies is the plaque-reduction neutralization test that is specific but also time-consuming and laborious. Therefore, a rapid and reliable method was developed to determine neutralizing antibody titers within twelve hours. The new assay measures viral mRNA transcription as a marker for actively replicating virus after incomplete neutralization using real-time PCR.

© 2011 Kramski et al; licensee BioMed Central Ltd.

PMID:
21439060
[PubMed - indexed for MEDLINE]
PMCID:
PMC3073888
Free PMC Article

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