Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Diab Rep. 2011 Jun;11(3):154-9. doi: 10.1007/s11892-011-0191-1.

Gut microbiota and the pathogenesis of insulin resistance.

Author information

  • 1Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Universit√© Catholique de Louvain, Brussels, Belgium. nathalie.delzenne@uclouvain.be

Abstract

Several reviews recently explored how the gut microbiota was able to control host energy metabolism, and thereby the development of adiposity. In this review, we focused on the state of the art that supports a link between the gut microbiota composition and activity, and the management of glycemia associated with overweight and diabetes. Several microbial-derived compounds are related to disturbances of glucose homeostasis including the gram-negative-derived lipopolysaccharides. Some nutrients with prebiotic properties, which escape the digestion in the upper part of the gut, modify the composition of the gut microbiota in favor of bacteria that could play a beneficial role on glucose homeostasis, namely by modulating the endocrine function of the gut, and by reinforcing the gut barrier. Adequate intervention studies in diabetic patients are required to assess the relevance of those experimental data for human health.

PMID:
21431853
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Springer
    Loading ...
    Write to the Help Desk