Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Indian J Psychiatry. 2011 Jan;53(1):25-9. doi: 10.4103/0019-5545.75557.

Status of disulfiram in present day alcoholic deaddiction therapy.

Author information

  • 1Department of Pharmacology, Fr. Muller Medical College, Mangalore - 575 002, India.

Abstract

AIM:

Assessment of safety and efficacy profile of disulfiram (DSM) in the alcoholic de-addiction regimen.

OBJECTIVES:

a. Assessment of Adverse Drug Reaction (ADR) profile; b. Evaluation of effectiveness of various deaddiction regimen; c. Defaulters and dropouts

PATIENTS AND METHODS:

Fifty-one patients in a de-addiction center were investigated on 0(th) , 30(th) and 60(th) day along with psychiatric evaluation, ADR surveillance was made. Statistical analysis was done thereafter.

RESULTS:

125 mg DSM given OD for 2 months. 76.5% patients had taken full course of treatment, 45% didn't complain of any ADR. Of ADR reported 27.4% had drowsiness, 21.4% tiredness, 7.8% skin manifestation.

CONCLUSION:

DSM is the main drug among naltrexone, acamprosate, nalmefene and other drugs used in alcoholic de-addiction. Relative and effectiveness is lost by the degree of dropouts and hence relapses. Low-dose DSM had decreased adverse effects with 76.5% patients taking the full course of treatment. DSM alters liver functions as there were significant changes in the lab parameters of SGPT(P=0.007), SGOT(P=0.001), GGT(P=<0.001) between first and third samples. Occurrence of ADR is not the cause of default; patients find it confusing to differentiate between the symptoms of alcohol withdrawal and those due to ADR of DSM.

KEYWORDS:

Adverse drug reaction; alcohol de-addiction; de-addiction regimen; disulfiram; drug default

PMID:
21431004
[PubMed]
PMCID:
PMC3056183
Free PMC Article

Images from this publication.See all images (10)Free text

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Medknow Publications and Media Pvt Ltd Icon for PubMed Central
    Loading ...
    Write to the Help Desk