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J Child Neurol. 2011 Jun;26(6):692-702. doi: 10.1177/0883073810388646. Epub 2011 Mar 22.

Survey of aspirin use in Sturge-Weber syndrome.

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  • 1Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, MD, USA.

Abstract

Sturge-Weber syndrome is a rare congenital disorder. Seizures, stroke-like episodes, glaucoma, headache, and developmental delay are frequently associated features. An Internet-based questionnaire was designed to assess the frequency of use, effectiveness, and safety of aspirin treatment in Sturge-Weber syndrome. Thirty-four of 98 subjects who completed the survey reported having used aspirin. The mean number of reported stroke-like episodes was reduced from 1.1 to 0.3 per month in the year after starting aspirin (n = 26, p = .014). The median number of seizures was significantly reduced from 3 to 1 episodes per month (n = 21, p = .002). Thirty-nine percent of subjects reported a history of complications (predominantly increased bruising or gum/nose bleeding) while on aspirin; however, none reported discontinuing aspirin because of side effects. Our study showed a significant relative reduction in both self-reported seizure frequency and stroke-like episodes after starting aspirin. It also suggests that low-dose aspirin can be safely used in these patients.

PMID:
21427442
[PubMed - indexed for MEDLINE]
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