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    Chem Commun (Camb). 2011 May 7;47(17):4998-5000. doi: 10.1039/c1cc10161g. Epub 2011 Mar 22.

    A smart magnetic resonance imaging contrast agent responsive to adenosine based on a DNA aptamer-conjugated gadolinium complex.

    Xu W, Lu Y.

    Source

    Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois, USA.

    Abstract

    We report a general strategy for developing a smart MRI contrast agent for the sensing of small molecules such as adenosine based on a DNA aptamer that is conjugated to a Gd compound and a protein streptavidin. The binding of adenosine to its aptamer results in the dissociation of the Gd compound from the large protein, leading to decreases in the rotational correlation time and thus change of MRI contrast.

    © The Royal Society of Chemistry 2011

    PMID:
    21424019
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC3298773
    Free PMC Article

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