Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Front Psychiatry. 2010 Jun 3;1:15. doi: 10.3389/fpsyt.2010.00015. eCollection 2010.

The Relationship between Parkin and Protein Aggregation in Neurodegenerative Diseases.

Author information

  • 1Department of Neuroscience, Georgetown University Medical Center Washington, DC, USA.

Abstract

The most prominent changes in neurodegenerative diseases are protein accumulation and inclusion formation. Several neurodegenerative diseases, including Alzheimer's, the Synucleinopathies and Tauopathies share several overlapping clinical symptoms manifest in Parkinsonism, cognitive decline and dementia. As degeneration progresses in the disease process, clinical symptoms suggest convergent pathological pathways. Biochemically, protein cleavage, ubiquitination and phosphorylation seem to play fundamental roles in protein aggregation, inclusion formation and inflammatory responses. In the following we provide a synopsis of the current knowledge about protein accumulation and astrogliosis as a common denominator in neurodegenerative diseases, and we propose insights into protein degradation and anti-inflammation. We review the E3-ubiquitin ligase and other possible functions of parkin as a suppressant of inflammatory signs and a strategy to clear amyloid proteins in neurodegenerative diseases.

KEYWORDS:

Aβ; Synucleinopathies; TDP-43; Tau; Tauopathies; dementia; parkin; α-Synuclein

PMID:
21423426
[PubMed]
PMCID:
PMC3059628
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Frontiers Media SA Icon for PubMed Central
    Loading ...
    Write to the Help Desk