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Antimicrob Agents Chemother. 2011 Jun;55(6):2979-82. doi: 10.1128/AAC.01582-10. Epub 2011 Mar 21.

A novel gene cassette, aacA43, in a plasmid-borne class 1 integron.

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  • 1Centre for Infectious Diseases and Microbiology, Level 3, ICPMR Building, Westmead Hospital, Wentworthville, New South Wales 2145, Australia.


A novel gene cassette, aacA43, was identified in the aadB-aacA43-oxa10-smr2 cassette array in a class 1 integron. Like related aminoglycoside-(6')-acetyltransferases, AacA43 confers clinically relevant resistance to kanamycin, tobramycin, and some less-used aminoglycosides but not to gentamicin. Although transferable on an IncL/M plasmid, aacA43 was identified in only two different Klebsiella pneumoniae strains (14 isolates), one Escherichia coli strain (2 isolates), and one Enterobacter cloacae strain in a survey of patients in a Sydney intensive care unit in 2004-2005.

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