Clin Breast Cancer. 2011 Mar;11(1):67-70.

Morphea as a consequence of accelerated partial breast irradiation.

Wernicke AG, Goltser Y, Trichter S, Sabbas A, Gaan J, Swistel AJ, Magro CM.

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Department of Radiation Oncology, Weill Medical College of Cornell University, New York, NY 10065, USA. gaw9008@med.cornell.edu

Abstract

Morphea is a localized form of scleroderma usually unaccompanied by the typical systemic stigmata that characterize progressive systemic scleroderma. It rarely manifests at the site of whole breast external-beam radiation therapy. We present an unusual case of radiation-induced morphea (RIM) that occurred after accelerated partial breast irradiation (APBI) using intracavitary Contura brachytherapy. A 65-year-old white woman was treated for stage IIA invasive ductal carcinoma of the left breast with APBI to a dose of 34 Gy in 3.4-Gy fractions twice daily over the course 5 days with intracavitary brachytherapy. At 1.5 years after completion of APBI, the patient developed an area of tenderness, erythema, and induration at the site of irradiation. A skin biopsy was consistent with morphea. To our knowledge, this is the first case of RIM confined to the area of APBI.

PMID:: 21421525; [PubMed - indexed for MEDLINE]

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