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Bioorg Med Chem Lett. 2011 Apr 15;21(8):2351-3. doi: 10.1016/j.bmcl.2011.02.081. Epub 2011 Feb 26.

N5-phosphonoacetyl-L-ornithine (PALO): a convenient synthesis and investigation of influence on regulation of amino acid biosynthetic genes in Saccharomyces cerevisiae.

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  • 1Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588-0304, USA.


A scalable four-step synthesis of the ornithine transcarbamylase inhibitor N(5)-phosphonoacetyl-l-ornithine (PALO) is achieved through boroxazolidinone protection of ornithine. Investigations in the model organism Saccharomyces cerevisiae found that, in contrast to a previous report, PALO did not influence growth rate or expression of genes involved in arginine metabolism.

Copyright © 2011 Elsevier Ltd. All rights reserved.

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