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Curr Biol. 2011 Mar 22;21(6):R227-9. doi: 10.1016/j.cub.2011.02.007.

Autophagy: regulation by energy sensing.

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  • 1Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands. a.j.meijer@amc.uva.nl


Autophagy is inhibited by the mTOR signaling pathway, which is stimulated by increased amino acid levels. When cellular energy production is compromised, AMP-activated protein kinase is activated, mTOR is inhibited and autophagy is stimulated. Two recent studies have shed light on the molecular mechanism by which AMPK controls autophagic flux.

Copyright © 2011 Elsevier Ltd. All rights reserved.

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