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J Craniomaxillofac Surg. 2011 Dec;39(8):628-32. doi: 10.1016/j.jcms.2011.01.003. Epub 2011 Mar 17.

Bone quality of mandibles reconstructed with particulate cellular bone and marrow, and platelet-rich plasma.

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  • 1Department of Oral and Maxillofacial Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan. matsuoam@tokyo-med.ac.jp


The purpose of this study was to evaluate the bone quality of mandibles reconstructed with particulate cellular bone and marrow (PCBM) and platelet-rich plasma (PRP). We compared the bone mineral density (BMD) and microstructure of PCBM and PRP-reconstructed bone and normal bone in patients. Bone biopsies were taken of 11 samples of PCBM and PRP reconstructed bone and 16 samples of normal bone using a trephine bur. BMD and microstructures were assessed using microcomputed tomography. The compact bone resulting from the PCBM and PRP reconstruction was extremely thin. Analysis of the microstructures, showed statistically significant differences only in trabecular bone number and trabecular bone spaces between PCBM and PRP-reconstructed bones and normal bones. In the case of BMD, no statistical differences were found between the two groups. Lamellar structures and osteocytes were observed histologically in the trabecular bone in both groups. In conclusion, the BMD and microstructures of the cancellous bone in the PCBM and PRP-reconstructed mandibles resembled those in the normal mandibles.

Copyright © 2011 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

[PubMed - indexed for MEDLINE]
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