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Neurosci Lett. 2011 May 9;495(1):55-9. doi: 10.1016/j.neulet.2011.03.034. Epub 2011 Mar 23.

Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia.

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  • 1Department of Neurobiology and Behavior, University of California, Irvine, CA, United States.


The risk of Alzheimer's disease increases following cerebral hypoperfusion. We studied the long-term interaction between low blood flow to the brain and Alzheimer's disease by inducing a transient global ischemic insult in aged 3xTg-AD mice and determining the effects on AD pathology 3-months post injury. We found that global ischemia does not increase the levels of amyloid-β in these mice. However, the injury did lead to enhanced phosphorylation of the amyloid precursor protein (APP) at the Thr668 site in both the 3xTg-AD mice and wild-type controls. Furthermore, we found an increase in insoluble total tau 3-months post-injury. Together these findings further elucidate the long-term impact of cerebral hypoperfusion on Alzheimer's disease.

Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

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