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J Am Chem Soc. 2011 Apr 13;133(14):5163-5. doi: 10.1021/ja110879m. Epub 2011 Mar 18.

Base pairing enhances fluorescence and favors cyclobutane dimer formation induced upon absorption of UVA radiation by DNA.

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  • 1CNRS, IRAMIS, SPAM, Laboratoire Francis Perrin, URA 2453, 91191 Gif-sur-Yvette, France.


The photochemical properties of the DNA duplex (dA)(20)·(dT)(20) are compared with those of the parent single strands. It is shown that base pairing increases the probability of absorbing UVA photons, probably due to the formation of charge-transfer states. UVA excitation induces fluorescence peaking at ∼420 nm and decaying on the nanosecond time scale. The fluorescence quantum yield, the fluorescence lifetime, and the quantum yield for cyclobutane dimer formation increase upon base pairing. Such behavior contrasts with that of the UVC-induced processes.

© 2011 American Chemical Society

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