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Methods Mol Biol. 1991;7:109-28. doi: 10.1385/0-89603-178-0:109.

Manipulation of adenovirus vectors.

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  • 1Departments of Biology and Patholo, McMaster University, Hamilton, Ontario, Canada.


Adenoviruses have been isolated from a large number of different species (mammalian and fowl) and over 100 different serotypes have been reported, some 43 of them human. The human adenoviruses, particularly types 2, 5, and 12, have been the most extensively characterized, and these viruses have served as valuable tools in the study of the molecular biology of DNA replication, transcription, RNA processing, and protein synthesis in mammalian cells. Seeref. 1 for a general review.

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