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Aging (Albany NY). 2011 Mar;3(3):319-24.

The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae.

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  • 1School of Biological Sciences, Research Center for Functional Cellulomics, Institute of Microbiology, Seoul National University, Republic of Korea.


The target of rapamycin (TOR) pathway regulates cell growth and aging in various organisms. In Saccharomyces cerevisiae, silent information regulator 2 (Sir2) modulates cellular senescence. Moreover, Sir2 plays a crucial role in promoting ribosomal DNA (rDNA) stability and longevity under TOR inhibition. Here we review the implication of rDNA stabilizers in longevity, discuss how Sir2 stabilizes rDNA under TOR inhibition and speculate on the link between sumoylation and Sir2-related pro-aging pathways.

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