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Cell. 2011 Mar 18;144(6):986-98. doi: 10.1016/j.cell.2011.02.016.

Interactome networks and human disease.

Author information

  • 1Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. marc_vidal@dfci.harvard.edu

Abstract

Complex biological systems and cellular networks may underlie most genotype to phenotype relationships. Here, we review basic concepts in network biology, discussing different types of interactome networks and the insights that can come from analyzing them. We elaborate on why interactome networks are important to consider in biology, how they can be mapped and integrated with each other, what global properties are starting to emerge from interactome network models, and how these properties may relate to human disease.

Copyright © 2011 Elsevier Inc. All rights reserved.

PMID:
21414488
[PubMed - indexed for MEDLINE]
PMCID:
PMC3102045
Free PMC Article

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