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Part I. Chromatin Protein Complexes: Dynamic Assemblies in the Nucleus.

Authors

Jovin D.

Source

Mapping Protein/DNA Interactions by Cross-Linking [Internet]. Paris: Institut national de la santé et de la recherche médicale; 2001.

Excerpt

Our research focuses on the influence of specific repressor and activator complexes on nuclear architecture in the context of Drosophila development using a combination of fluorescence in situ hybridization, specific GFP--protein constructs, and immunofluorescence in high-resolution imaging microscopy. I will discuss the Polycomb-group repression complex, which maintains silencing of the homeobox genes in specific tissues throughout development, and the MSL dosage compensation complex, which up-regulates the level of transcription of genes on the X chromosome in males.

Copyright © 2001, Institut national de la santé et de la recherche médicale (INSERM)

PMID:
21413359
[PubMed]
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