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Head Neck. 2012 Mar;34(3):305-12. doi: 10.1002/hed.21735. Epub 2011 Mar 16.

Noninvasive imaging of oral neoplasia with a high-resolution fiber-optic microendoscope.

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  • 1Rice University Department of Bioengineering, 6100 Main Street, Houston, Texas 77005, USA.

Abstract

BACKGROUND:

The purpose of this study was to evaluate the ability of high-resolution microendoscopy to image and quantify changes in cellular and architectural features seen in early oral neoplasia in vivo.

METHODS:

A high-resolution microendoscope (HRME) was used to image intact, resected oral squamous carcinoma specimens. HRME images were reviewed and classified as non-neoplastic or neoplastic by expert clinicians. An algorithm based on quantitative morphologic features was also used to classify each image. Results were compared to the histopathologic diagnosis.

RESULTS:

HRME images were obtained from 141 sites in resected specimens from 13 patients. Subjective image interpretation yielded sensitivity and specificity of 85% to 90% and 80% to 85%, respectively, whereas the objective classification algorithm achieved sensitivity and specificity of 81% and 77%, respectively.

CONCLUSION:

High-resolution microendoscopy of intact oral mucosa can provide images with sufficient detail to classify oral lesions by both subjective image interpretation and objective image analysis.

Copyright © 2011 Wiley Periodicals, Inc.

PMID:
21413101
[PubMed - indexed for MEDLINE]
PMCID:
PMC3078517
Free PMC Article
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