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Cochrane Database Syst Rev. 2011 Mar 16;(3):CD007879. doi: 10.1002/14651858.CD007879.pub2.

Hepatitis B vaccination during pregnancy for preventing infant infection.

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  • 1Department of Obstetrics and Gynaecology, Khon Kaen Hospital, Srichan Road, Maung, Khon Kaen, Thailand, 40000.

Abstract

BACKGROUND:

Infant hepatitis B infection increases risk of chronic infection, cirrhosis or liver cancer (hepatocellular carcinoma) in adult. Perinatal transmission is a common route of infection.

OBJECTIVES:

To assess the effectiveness and adverse effects of hepatitis B vaccine administered to pregnant women for preventing hepatitis B virus infection in infants.

SEARCH STRATEGY:

We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 December 2010).

SELECTION CRITERIA:

Randomized controlled trials (RCTs) assessing hepatitis B vaccination compared with placebo or no treatment during pregnancy for preventing infant infection. We excluded quasi-RCTs and crossover studies.

DATA COLLECTION AND ANALYSIS:

Two review authors independently assessed trial eligibility.

MAIN RESULTS:

We were not able to include any studies.

AUTHORS' CONCLUSIONS:

We found no RCTs that assessed the effects of hepatitis B vaccine during pregnancy for preventing infant infection. Consequently, this review cannot provide guidance for clinical practice in this area. However, it does identify the need for well-designed randomized clinical trials for the effect of hepatitis B vaccine during pregnancy on the incidence of infant infection and adverse effects.

PMID:
21412913
[PubMed - indexed for MEDLINE]
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