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    Macromolecules. 2010 Aug 24;43(16):6577-6587.

    Effect of Mass Transport in the Synthesis of Partially Acetylated Dendrimer: Implications for Functional Ligand-Nanoparticle Distributions.

    Mullen DG, Borgmeier EL, Fang M, McNerny DQ, Desai A, Baker JR Jr, Orr BG, Holl MM.

    Source

    Program in Macromolecular Science and Engineering, University of Michigan, Ann Arbor, Michigan 48109.

    Abstract

    Partial acetylation of the amine-terminated poly(amidoamine) dendrimer has been used in the preparation of dendrimer particles conjugated with a wide variety of functional ligands including targeting moieties, therapeutic agents, and dye molecules. The effectiveness of mass transport during the partial acetylation reaction was found to have a major effect on subsequent distributions of dendrimer-ligand components and to be a major source of inconsistency between batches. This study has broad implications for a wide range of nanoparticle-ligand systems because it demonstrates that conjugates with the same mean ligand-particle ratios can have completely different distribution profiles.

    PMID:
    21412444
    [PubMed]
    PMCID:
    PMC3056448
    Free PMC Article

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