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Clin Cancer Res. 2011 Mar 15;17(6):1215-7. doi: 10.1158/1078-0432.CCR-10-3446.

Moving closer to a prognostic DNA methylation signature in colon cancer.

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  • 1Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain.


Although large panels of genes undergoing aberrant CpG island methylation in colorectal cancer have been identified, reliable predictors for clinical management in this tumor type remain elusive. A new DNA methylation signature affecting the extracellular matrix (ECM) pathway has been identified with potential prognostic value in colon cancer.

©2011 AACR.

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