Amino Acids. 2011 May;40(5):1385-96. Epub 2011 Mar 15.

Creatine as an antioxidant.

Sestili P, Martinelli C, Colombo E, Barbieri E, Potenza L, Sartini S, Fimognari C.

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Dipartimento di Scienze Biomolecolari, Università degli Studi di Urbino Carlo Bo, Via Saffi 2, Urbino, Italy. piero.sestili@uniurb.it

Abstract

Creatine monohydrate (Cr), the most diffuse supplement in the sports industry, is receiving greater attention because of its beneficial effects in a wide number of human degenerative diseases and conditions. These effects can be barely explained on the basis of the sole ergogenic role of the Cr/CrP system. Indeed, a wide number of research articles indicate that Cr is capable of exerting multiple, non-energy related, effects on diverse and relevant cellular targets. Among these effects, the antioxidant activity of Cr emerges as an additional mechanism which is likely to play a supportive role in the Cr-cytoprotection paradigm.

PMID:: 21404063; [PubMed - indexed for MEDLINE]

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