J Affect Disord. 1990 Apr;18(4):259-66.

Predictors of outcome in prophylactic lithium treatment: a 2-year prospective study.

Source

Clinical Department A, Institute of Psychiatric Demography, Aarhus Psychiatric Hospital, Risskov, Denmark.

Abstract

The purpose of this study of 133 affective disorder patients consecutively referred to start prophylactic lithium treatment was to identify informative predictors of outcome. Non-adherence to treatment was mainly predicted by substance abuse and many earlier admissions. Non-response among the 78 patients adhering to lithium treatment was mainly predicted by female sex, young age and previously chronic course. The overall response rate was rather poor and an excess mortality rate was found. It is suggested that patients with substance abuse should not be offered prophylactic lithium treatment unless intensive control and support is practicable, and patients with a chronic course need a more effective treatment than lithium can offer.

PMID:: 2140378; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

Lithium

LinkOut - more resources

Medical

Bipolar Disorder - MedlinePlus Health Information

Molecular Biology Databases

LITHIUM, ELEMENTAL - HSDB

Supplemental Content

Save items

Related citations in PubMed

Long-term outcome of patients with bipolar disorder commenced on lithium prophylaxis during hospitalization: a complete 15-year register-based follow-up. [Bipolar Disord. 2008]
Long-term outcome of patients with bipolar disorder commenced on lithium prophylaxis during hospitalization: a complete 15-year register-based follow-up.
Licht RW, Vestergaard P, Brodersen A. Bipolar Disord. 2008 Feb; 10(1):79-86.
Review [Predictors of prophylactic response to lithium]. [Encephale. 2008]
Review [Predictors of prophylactic response to lithium].
Rohayem J, Baylé JF, Richa S. Encephale. 2008 Sep; 34(4):394-9. Epub 2007 Nov 26.
Review Prevention of suicide and attempted suicide in Denmark. Epidemiological studies of suicide and intervention studies in selected risk groups. [Dan Med Bull. 2007]
Review Prevention of suicide and attempted suicide in Denmark. Epidemiological studies of suicide and intervention studies in selected risk groups.
Nordentoft M. Dan Med Bull. 2007 Nov; 54(4):306-69.
Efficacy of lithium prophylaxis in clinical practice. [Br J Psychiatry. 1989]
Efficacy of lithium prophylaxis in clinical practice.
Markar HR, Mander AJ. Br J Psychiatry. 1989 Oct; 155:496-500.
Outcome of bipolar disorder on long-term treatment with lithium. [Br J Psychiatry. 1991]
Outcome of bipolar disorder on long-term treatment with lithium.
O'Connell RA, Mayo JA, Flatow L, Cuthbertson B, O'Brien BE. Br J Psychiatry. 1991 Jul; 159:123-9.

See reviews... See all...

Cited by 7 PubMed Central articles

Efficacy of lithium prophylaxis in bipolar affective disorder. [Indian J Psychiatry. 1995]
Efficacy of lithium prophylaxis in bipolar affective disorder.
Mathew MR, Chandrasekaran R, Shreeram SS, Anand I. Indian J Psychiatry. 1995 Jan; 37(1):5-8.
A randomized, double-blind, placebo-controlled pilot study of naltrexone in outpatients with bipolar disorder and alcohol dependence. [Alcohol Clin Exp Res. 2009]
A randomized, double-blind, placebo-controlled pilot study of naltrexone in outpatients with bipolar disorder and alcohol dependence.
Brown ES, Carmody TJ, Schmitz JM, Caetano R, Adinoff B, Swann AC, John Rush A. Alcohol Clin Exp Res. 2009 Nov; 33(11):1863-9. Epub 2009 Aug 10.
Treatment of depressed bipolar patients with alcohol use disorders: plenty of room for improvement. [J Affect Disord. 2009]
Treatment of depressed bipolar patients with alcohol use disorders: plenty of room for improvement.
Baca-Garcia E, Sher L, Perez-Rodriguez MM, Burke AK, Sullivan GM, Grunebaum MF, Stanley BH, Mann JJ, Oquendo MA. J Affect Disord. 2009 May; 115(1-2):262-8. Epub 2008 Oct 29.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Predictors of outcome in prophylactic lithium treatment: a 2-year prospective st...
Predictors of outcome in prophylactic lithium treatment: a 2-year prospective study.
J Affect Disord. 1990 Apr ;18(4):259-66.

PubMed
Conservative management of a case of medial epicondylosis in a recreational squa...
Conservative management of a case of medial epicondylosis in a recreational squash player.
J Can Chiropr Assoc. 2011 Mar ;55(1):26-31.

PubMed
Central nervous system toxicity of tricyclic antidepressants: phenomenology, cou...
Central nervous system toxicity of tricyclic antidepressants: phenomenology, course, risk factors, and role of therapeutic drug monitoring.
J Clin Psychopharmacol. 1990 Apr ;10(2):88-95.

PubMed
Proteinuria in a patient with diabetes.
Proteinuria in a patient with diabetes.
Kidney Int. 2011 Apr ;79(7):793-4.

PubMed
Inspiratory and expiratory muscle function during continuous positive airway pre...
Inspiratory and expiratory muscle function during continuous positive airway pressure in dogs.
J Appl Physiol. 1990 Mar ;68(3):1092-100.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: