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Antimicrob Agents Chemother. 2011 Jun;55(6):3022-4. doi: 10.1128/AAC.01732-10. Epub 2011 Mar 14.

Insertion sequence ISAba11 is involved in colistin resistance and loss of lipopolysaccharide in Acinetobacter baumannii.

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  • 1Department of Microbiology, Monash University, Victoria, Australia.

Abstract

Infections caused by Acinetobacter baumannii are of increasing concern, largely due to the multidrug resistance of many strains. Here we show that insertion sequence ISAba11 movement can result in inactivation of the A. baumannii lipid A biosynthesis genes lpxA and lpxC, resulting in the complete loss of lipopolysaccharide production and high-level colistin resistance.

PMID:
21402838
[PubMed - indexed for MEDLINE]
PMCID:
PMC3101452
Free PMC Article

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