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    Transpl Int. 2011 Jun;24(6):619-26. doi: 10.1111/j.1432-2277.2011.01246.x. Epub 2011 Mar 14.

    Donor haptoglobin phenotype determines outcome following liver transplantation.

    Speeckaert R, Van Vlierberghe H, Troisi R, De Bacquer D, Speeckaert MM, De Buyzere ML, Claeys L, de Hemptinne B, Delanghe JR.

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    Department of Clinical Chemistry, Ghent University Hospital, De Pintelaan 85, Gent, Belgium.

    Abstract

    Haptoglobin (Hp) is a polymorphic plasma protein with multiple functions defined by three major phenotypes (Hp 1-1, Hp 2-1, and Hp 2-2). In this article, the effects of the donor Hp phenotype (determined by starch gel electrophoresis) on the outcome and the iron status after liver transplantation were investigated. A total of 450 liver transplant patients were enrolled in this study with a median follow-up of 37 months. Kaplan-Meier and Cox regression survival analyses showed a significantly worse graft survival for liver transplantation cases with an Hp 2-2 donor phenotype, which was associated with an increased mortality rate in this group. In male patients, the Hp 2-2 phenotype was associated with higher serum ferritin concentrations, which may be linked to the significantly increased likelihood of infectious complications in this phenotype. Liver transplant patients with Hp 1-1 and Hp 2-1 grafts had a better outcome probability than recipients of an Hp 2-2 graft, which may be explained by differences in iron metabolism induced by the Hp genotype of the graft.

    © 2011 The Authors. Transplant International © 2011 European Society for Organ Transplantation.

    PMID:
    21401731
    [PubMed - indexed for MEDLINE]

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