Immunol Today. 1990 Mar;11(3):75-8.

Positive selection of gamma delta T cells.

Lafaille JJ, Haas W, Coutinho A, Tonegawa S.

Source

Howard Hughes Medical Institute, Center for Cancer Research, Cambridge, MA.

Abstract

The issue of T-cell repertoire selection has been addressed recently by several laboratories. While evidence has been provided for both negative and positive selection of CD4+ and CD8+ alpha beta T cells, the molecular basis of positive selection remains unclear. In this article Juan Lafaille and colleagues describe molecular features of gamma delta T-cell selection in the fetal thymus. These features were deduced from extensive junctional sequence data of gamma delta T-cell receptor genes in fetal thymocytes. Their data suggest the active participation of a self peptide in the positive selection of gamma delta T cells.

PMID:: 2140041; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

EBSCO

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

The expression and sequences of T cell antigen receptor beta-chain genes in the thymus at an early stage after sublethal irradiation. [J Immunol. 1989]
The expression and sequences of T cell antigen receptor beta-chain genes in the thymus at an early stage after sublethal irradiation.
Yuuki H, Yoshikai Y, Kishihara K, Matsuzaki G, Ayukawa K, Nomoto K. J Immunol. 1989 May 15; 142(10):3683-91.
The adult T-cell receptor delta-chain is diverse and distinct from that of fetal thymocytes. [Nature. 1988]
The adult T-cell receptor delta-chain is diverse and distinct from that of fetal thymocytes.
Elliott JF, Rock EP, Patten PA, Davis MM, Chien YH. Nature. 1988 Feb 18; 331(6157):627-31.
Origin, differentiation, and repertoire selection of CD3+CD4-CD8- thymocytes bearing either alpha beta or gamma delta T cell receptors. [J Immunol. 1993]
Origin, differentiation, and repertoire selection of CD3+CD4-CD8- thymocytes bearing either alpha beta or gamma delta T cell receptors.
Suda T, Zlotnik A. J Immunol. 1993 Jan 15; 150(2):447-55.
Review [Positive and negative selection of thymocytes]. [Zhongguo Yi Xue Ke Xue Yuan Xu...]
Review [Positive and negative selection of thymocytes].
Wu D, Zhu LP, He W. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2002 Oct; 24(5):530-2.
Review Cross-talk between the T cell antigen receptor and the glucocorticoid receptor regulates thymocyte development. [Stem Cells. 1996]
Review Cross-talk between the T cell antigen receptor and the glucocorticoid receptor regulates thymocyte development.
Ashwell JD, King LB, Vacchio MS. Stem Cells. 1996 Sep; 14(5):490-500.

See reviews... See all...

Cited by 7 PubMed Central articles

Selection of gamma delta T cells with canonical T-cell antigen receptors in fetal thymus. [Proc Natl Acad Sci U S A. 1990]
Selection of gamma delta T cells with canonical T-cell antigen receptors in fetal thymus.
Itohara S, Tonegawa S. Proc Natl Acad Sci U S A. 1990 Oct; 87(20):7935-8.
Localization of gamma/delta T cells to the intestinal epithelium is independent of normal microbial colonization. [J Exp Med. 1990]
Localization of gamma/delta T cells to the intestinal epithelium is independent of normal microbial colonization.
Bandeira A, Mota-Santos T, Itohara S, Degermann S, Heusser C, Tonegawa S, Coutinho A. J Exp Med. 1990 Jul 1; 172(1):239-44.
Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation. [EMBO J. 1990]
Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation.
Gu H, Förster I, Rajewsky K. EMBO J. 1990 Jul; 9(7):2133-40.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Positive selection of gamma delta T cells.
Positive selection of gamma delta T cells.
Immunol Today. 1990 Mar ;11(3):75-8.

PubMed
Sexual and relationship satisfaction among heterosexual men and women: the impor...
Sexual and relationship satisfaction among heterosexual men and women: the importance of desired frequency of sex.
J Sex Marital Ther. 2011 ;37(2):104-15.

PubMed
Transcript catalogs of human chromosome 21 and orthologous chimpanzee and mouse ...
Transcript catalogs of human chromosome 21 and orthologous chimpanzee and mouse regions.
Mamm Genome. 2011 Jun ;22(5-6):261-71. Epub 2011 Mar 13 .

PubMed
Preclinical evaluation of the antitumor activity of bortezomib in combination wi...
Preclinical evaluation of the antitumor activity of bortezomib in combination with vitamin C or with epigallocatechin gallate, a component of green tea.
Cancer Chemother Pharmacol. 2011 Nov ;68(5):1145-54. Epub 2011 Mar 13 .

PubMed
NMR solution structure of subunit E (fragment E(1-69)) of the Saccharomyces cere...
NMR solution structure of subunit E (fragment E(1-69)) of the Saccharomyces cerevisiae V (1)V (O) ATPase.
J Bioenerg Biomembr. 2011 Apr ;43(2):187-93. doi: 10.1007/s10863-011-9342-y. Epub 2011 Mar 12 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: