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Dev Cell. 2011 Mar 15;20(3):285-7. doi: 10.1016/j.devcel.2011.02.009.

The ins and outs of heterochromatic DNA repair.

Author information

  • Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA. craig.peterson@umassmed.edu

Abstract

Repetitive DNA is often packaged into heterochromatin structures that prevent illicit recombination events that cause genomic instability. A recent study by Chiolo et al. (2011) published in Cell finds that DNA double-strand breaks formed within heterochromatin are shuttled to adjacent sites that are "safe" to complete repair by recombination.

Copyright © 2011 Elsevier Inc. All rights reserved.

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PMID:
21397838
[PubMed]
PMCID:
PMC3070314
Free PMC Article

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