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Structure. 2011 Mar 9;19(3):279-81. doi: 10.1016/j.str.2011.02.005.

Getting in the loop: new insights into the mechanism of poly(A) site recognition.

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  • 1Department of Genetics and Developmental Biology, University of Connecticut Stem Cell Institute, University of Connecticut Health Center, 400 Farmington Avenue, Farmington, CT 06030, USA.


In this issue, Yang et al. (2011) show that the 3' end processing factor CFI(m) interacts with RNA in manner that facilitates RNA looping, suggesting mechanistic roles for this factor in the regulation of poly(A) site selection.

Copyright © 2011 Elsevier Ltd. All rights reserved.

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