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Structure. 2011 Mar 9;19(3):277-9. doi: 10.1016/j.str.2011.02.006.

Pumilio RNA recognition: the consequence of promiscuity.

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  • 1Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, LRB-906, Worcester, MA 01605, USA.


In this issue, Lu and Hall (2011) reveal the structural basis for degenerate RNA recognition by human Pumilio proteins. The structures suggest an appealing model where nucleotides that do not contribute to binding affinity define Pumilio regulatory activity by adopting distinctive conformations with differential ability to recruit regulatory cofactors.

Copyright © 2011 Elsevier Ltd. All rights reserved.

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