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    Biochem Biophys Res Commun. 2011 Apr 8;407(2):378-82. Epub 2011 Mar 21.

    Critical role of the nucleolus in activation of the p53-dependent postmitotic checkpoint.

    Tsuchiya M, Katagiri N, Kuroda T, Kishimoto H, Nishimura K, Kumazawa T, Iwasaki N, Kimura K, Yanagisawa J.

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    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba Science City, Ibaraki 305-8572, Japan.

    Abstract

    Cells eventually exit from mitosis during sustained arrest at the spindle checkpoint, without sister chromatid separation and cytokinesis. The resulting tetraploid cells are arrested in the subsequent G1 phase in a p53-dependent manner by the regulatory function of the postmitotic G1 checkpoint. Here we report how the nucleolus plays a critical role in activation of the postmitotic G1 checkpoint. During mitosis, the nucleolus is disrupted and many nucleolar proteins are translocated from the nucleolus into the cytoplasm. Among the nucleolar factors, Myb-binding protein 1a (MYBBP1A) induces the acetylation and accumulation of p53 by enhancing the interaction between p300 and p53 during prolonged mitosis. MYBBP1A-dependent p53 activation is essential for the postmitotic G1 checkpoint. Thus, our results demonstrate a novel nucleolar function that monitors the prolongation of mitosis and converts its signal into activation of the checkpoint machinery.

    Copyright © 2011 Elsevier Inc. All rights reserved.

    PMID:
    21396915
    [PubMed - indexed for MEDLINE]

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