Format

Send to:

Choose Destination
See comment in PubMed Commons below
Am J Ophthalmol. 2011 Jun;151(6):999-1006.e4. doi: 10.1016/j.ajo.2010.11.029. Epub 2011 Mar 10.

Association of host genetic risk factors with the course of cytomegalovirus retinitis in patients infected with human immunodeficiency virus.

Collaborators (428)

Lewis RA, Bourg JM, Fainstein V, Krason Z, Morales JF, Orengo-Nania S, Samo TC, Spencer S, Weikert MP, Allen RC, Frady P, Gross R, Schmidt A, Shawver L, Shigley J, Slight B, Sotuyo R, Travers S, Srivastava SK, Gibbs A, Gibbs D, Jordan D, Myles B, Rutter J, Capone A Jr, Furukuwa D, Hubbard B, Martin DF, Goldman M, Brown J, Ciulla T, Craft J, Danis R, Fry P, Gao H, Gupta S, Hernandez J, Poe D, Pratt L, Richardson JD, Steffens T, Wheat LJ, Zwickl B, Dunn JP, Brown DM, Cain D, Emmert D, Herring M, Jacobowitz A, Leder HA, Livingston AG, Morton Y, Nolan KD, Semba RD, Soto P, Thorne JE, Barditch-Crovo P, Bélair ML, Bolton SG, Brodine JB, Brune LM, Galor A, Jabs DA, Kapoor M, Kedhar SR, Kempen JH, Kim SJ, Oliver AL, Peters GB 3rd, Stevenson R, Tarver-Carr M, Wittenberg S, Wang MY, Bergsma D, Clark R, Cooper R, Elison J, Fuller B, Jarrott C, Otillio L, Reinoso M, Romero C, Barron B, Bye R, Conway M, Dillon L, Lombard A, Peyman G, Rescigno R, Bhagat N, Paez-Boham R, Paez-Quinde M, Heinemann MH, Chan RV, Cole C, Coleman S, Janis R, Kozbial A, Pachydaki S, Iglesias Rivera D, Sepkowitz K, Warden S, Boyd K, Chiu C, Doering C, Elison J, Lee S, Lu F, Murphy J, Peroni C, Rahhal FM, Reddy A, Friedberg DN, Addessi A, Dieterich D, Lorenzo-Latkany M, Pei M, McMeeking A, Lyon AT, Ackatz L, Gill M, Kaminski L, Mirza R, Murphy R, Palella F, Ramirez C, Rozenbajgier Z, Ryan D, Simjanoski E, Habib A, Koecher J, Mathura J, Muñana A, Shankle J, Weinberg DV, Yuhr J, MacCumber MW, Gaynes B, Giannoulis C, Hulvey P, Kessler H, Khan HS, Kopp A, Merrill P, Morini F, Smith N, Tenorio A, Voskuil-Marre D, Woo K, Kuppermann BD, Alexandiescu B, Forthal DN, Grijalva J, Jehan F, Lopez K, Magallon R, Moinfar N, Trump B, Vega M, Williams R, Holland GN, Almanzor RD, Carlson ME, Castellanos JT, Craddock JA, Gonzales S, Johiro AK, Kalyani PS, Kapamajian MA, LeBeck DL, Lipka KM, Ransome SS, Chafey SA, Charonis AC, Kappel PJ, Moe AA, Piñón G, Sanderson A, Shah KH, Stalling R, Thayer D, Vaudaux JD, Freeman WR, Cochran D, Kozak I, Loughran M, Magana L, Morrison V, Nguyen V, Oster S, Chaidhawanqual S, Cheng L, Clark T, Cleveland M, Gannon RL, Garcia C, Goldberg D, Hedaya J, Karavellas M, Kemper T, Kosobucki B, Mask A, Reagan N, Song MK, Torriani F, Wong D, Young T, Duncan J, Ballesteros F Jr, Bhisitkul R, Brown D, Clay D, Deiner M, Eubank D, Jacobson M, Lew M, Margolis T, Aberg J, Hoffman J, Irvine A, Larson J, Lawrence J, Narahara M, Trinidad M, Meredith TA, Barnhart S, Cantrell D, Garg S, Hartnett E, Landers MB, Moyer S, Wohl D, Betran S, DeBoer K, Eifrig D, Foley J, Jeffries A, Kylstra J, Longmire B, Myers S, N'Dure F, Oh KT, Pantell J, Pedersen S, Rich C, Sotelo CA, van der Horst C, Wadhvania S, Nichols CW, Bardsley M, Devine CC, Kostman J, Maguire A, Nyberg W, Smith L, Helker C, MacGregor R, McGibney K, Mickelberg K, Lim JI, Bhatti R, Canzano J, Chang TS, Charonis A, Chong L, Equi R, Fawzi A, Flaxel C, Garcia J, Klesert T, Kramer F, Levin L, Nichols T, Pelzek C, Podilla M, Richine L, Romo D, Sadda S, Scartozzi R, See R, Shiramizu K, Thomas M, Walonker AF, Walsh A, Wu Z, Pavan PR, Kelty P, Leto J, Oehler R, Saxon W, Sherouse S, Tordilla-Wadia J, Goldstein B, Gompf S, Hernandez B, Kramer A, Millard S, Nadler J, Paulter SE, Walker N, Davis G, Blem R, Bourg JM, Horna J, Kelso C, Krason Z, Li HK, Nguyen LC, Nolen R, Onarato M, Paar D, Rivas S, Seitz V, Spillar H, Uwaydat S, Jabs DA, Hilal Y, Nieves M, Pascual K, Slutsky J, Stevens M, Southall JC, Meinert CL, Ahuja A, Amend-Libercci DA, Collins KL, Collison BJ, Colvin R, Dodge J, Donithan M, Ewing C, Frick K, Holbrook JT, Isaacson MR, Jackson RM, Livingston H, McCaffrey L, Puhan M, Reyes G, Smith J, Smith M, Sugar E, Thorne JE, Tonascia JA, Van Natta ML, Wagoner A, Benham C, Foster G, Harle J, Kaplan Gilpin AM, Kempen JH, Martin BK, Min N, Murrow L, Oziemkowska MJ, Ng WP, Scott PE, Smothers E, West E, Woo C, Wu A, Zong A, Danis R, Chandler C, Gangaputra S, Guilfoil G, Hubbard L, Pauli T, Joyce J, Robinson N, Thayer D, Pak JW, Zhang G, Altaweel M, Armstrong J, Davis MD, Glaeser S, Hughes K, Hurlburt D, Kastorff L, Neider M, Traut T, Vanderhoof-Young M, Wabers H, Kurinij N, Jabs DA, Danis R, Kurinij N, Meinert CL, Thorne JE, Davis MD, Holbrook JT, Jabs DA, Danis R, Dunn JP, Holland GN, Isaccson MR, Jacobson M, Kurinij N, Lewis R, Nolan KD, Meinert CL, Nyberg W, Palella F, Thorne JE, Addessi A, Brune L, Clark R, Clark T, Davis J, Davis MD, Freeman WR, Friedberg D, Gilman J, Holbrook JT, Horna J, Hubbard L, Jacobson M, Martin DF, Meredith TA, Muñana A, Murphy R, Pavan PR, Spencer S, Steffens T, Thayer D, van der Horst C, Wallach F.

Abstract

PURPOSE:

To evaluate the effects of previously reported host genetics factors that influence cytomegalovirus (CMV) retinitis incidence, progression to acquired immune deficiency syndrome (AIDS), and efficacy of highly active antiretroviral therapy (HAART) for mortality, retinitis progression, and retinal detachment in patients with CMV retinitis and AIDS in the era of HAART.

DESIGN:

Prospective, multicenter, observational study.

METHODS:

Cox proportional hazards model based genetic association tests examined the influence of IL-10R1_S420L, CCR5-Δ32, CCR2-V64I, CCR5 promoter, and SDF-3'A polymorphisms among patients with mortality, retinitis progression, and retinal detachment. Participants were 203 European-American and 117 African-American patients with AIDS and CMV retinitis.

RESULTS:

European-American patients with the CCR5 +.P1.+ promoter haplotype showed increased risk for mortality (hazard ratio [HR] = 1.83; 95% confidence interval [CI]: 1.00-3.40; P = .05). Although the same haplotype also trended for increased risk for mortality in African-American patients, the result was not significant (HR = 2.28; 95% CI: 0.93-5.60; P = .07). However, this haplotype was associated with faster retinitis progression in African Americans (HR = 5.22; 95% CI: 1.54-17.71; P = .007). Increased risk of retinitis progression was also evident for African-American patients with the SDF1-3'A variant (HR = 3.89; 95% CI: 1.42-10.60; P = .008). In addition, the SDF1-3'A variant increased the retinal detachment risk in this patient group (HR = 3.05; 95% CI: 1.01-9.16; P = .05).

CONCLUSION:

Besides overall immune health, host genetic factors influence mortality, retinitis progression, and retinal detachment in patients with AIDS and CMV retinitis that are receiving HAART.

Published by Elsevier Inc.

PMID:
21396623
[PubMed - indexed for MEDLINE]
PMCID:
PMC3103625
Free PMC Article

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk